Promising Alzheimer’s drug may also improve memory in Down syndrome and normal aging

Journal Reference:

  1. Md. Mahiuddin Ahmed, Athena Ching-Jung Wang, Mihret Elos, Heidi J. Chial, Stefan Sillau, D. Adriana Solano, Christina Coughlan, Leila Aghili, Paige Anton, Neil Markham, Vanesa Adame, Katheleen J. Gardiner, Timothy D. Boyd, Huntington Potter. The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice. Neurobiology of Disease, 2022; 168: 105694 DOI: 10.1016/j.nbd.2022.105694

The drug sargramostim (GM-CSF, which stands for granulocyte-macrophage colony-stimulating factor) is the first to show memory improvement in Alzheimer’s patients in a phase II clinical trial. GM-CSF is a normal human protein that is safe and well-tolerated with over 30 years of FDA-approved use for other disorders.

A multidisciplinary team at the University of Colorado Anschutz Medical Campus studied the safety and tolerability of GM-CSF treatment and its effects on behavior and brain pathology in a mouse model of Down syndrome and in mice undergoing typical aging. The results reported in the journal Neurobiology of Disease suggest that GM-CSF has potential applicability to humans.

“People with Down syndrome are at higher risk for Alzheimer’s disease and previous work showed that GM-CSF improves cognition and brain pathology in Alzheimer’s disease patients. This new study shows that GM-CSF also, unexpectedly, improves cognition in mice that do not have Alzheimer’s disease,” said senior author Huntington Potter, PhD, professor of neurology at the University of Colorado School of Medicine, director of the University of Colorado Alzheimer’s and Cognition Center and director of Alzheimer’s disease research at the Linda Crnic Institute for Down Syndrome. All three groups are located on the CU Anschutz Medical Campus.

He adds, “Discovering a treatment that may help children and young adults with Down syndrome to develop their physical and mental capabilities is critical to improving their health and activities of daily living.”

The research team, led by Md. Mahiuddin Ahmed, PhD, discovered that treatment with GM-CSF, which has pro-inflammatory, anti-inflammatory and immune regulatory properties, reverses learning and memory deficits, the loss of certain nerve cells, and other abnormalities in the brain in a mouse model of Down syndrome and also improves cognition in normal aging mice. The human version of GM-CSF/sargramostim has already been shown to be effective in improving cognition in people with mild-to-moderate Alzheimer’s disease and in cancer patients. The findings support the hypothesis that GM-CSF/sargramostim may promote neuronal recovery from injury or from neurological disease through multiple mechanisms, some of which evidently enhance cognitive function.

The next step is to determine whether this treatment is safe, tolerable and efficacious in people with Down syndrome.

The CU Anschutz Medical Campus team was recently awarded a grant from the National Institutes of Health/National Institute on Aging to study sargramostim treatment in young adults with Down syndrome who do not show evidence of Alzheimer’s disease. They will investigate its safety and potential efficacy regarding cognitive function, quality of life measures and biomarkers associated with neuronal damage.

“We are breaking new ground in studying sargramostim for multiple, different disorders — Down syndrome and Alzheimer’s disease,” Potter said. “We hope that this therapy, already proven to be safe for other diseases, will greatly improve cognitive function in people with Down syndrome.”

The new NIH-funded project, co-directed by Potter and Peter Pressman, MD, from the CU department of neurology, will leverage collaborations between research teams on the CU Anschutz Medical Campus and at Colorado State University. They will work closely with the Linda Crnic Institute for Down Syndrome, which is an affiliate of the Global Down Syndrome Foundation (GLOBAL). GLOBAL is the leading Down syndrome organization successfully advocating for Down syndrome research funding at the NIH.

We wish to thank the author of this article for this incredible web content

Promising Alzheimer’s drug may also improve memory in Down syndrome and normal aging

Fuzzy Skunk