Gene mutations that contribute to head and neck cancer also provide ‘precision’ treatment targets

Journal Reference: Hoi-Lam Ngan, Chun-Ho Law, Yannie Chung Yan Choi, Jenny Yu-Sum Chan, Vivian Wai Yan Lui. Precision drugging of the MAPK pathway in head and neck cancer. npj Genomic Medicine, 2022; 7 (1) DOI: 10.1038/s41525-022-00293-1 Keys to targeting that vulnerability include individualized genomic analysis to identify a patient’s specific mutation, and finding the drugs … Read more

Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method – NovLink Home Mash S Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method We would like to say thanks to the author of this article for this remarkable web content Establishment of a pancreatic cancer … Read more

Human gene variant produces attention deficit disorder-like problems in mice

Journal Reference: Eryn Donovan, Cassandra Avila, Sarah Klausner, Vinay Parikh, Cristina Fenollar-Ferrer, Randy D. Blakely, Martin Sarter. Disrupted choline clearance and sustained acetylcholine release in vivo by a common choline transporter coding variant associated with poor attentional control in humans. The Journal of Neuroscience, 2022; JN-RM-1334-21 DOI: 10.1523/JNEUROSCI.1334-21.2022 The study, led by researchers from the … Read more

Gene linked to hearing in humans also linked to touch in sea anemones

Journal Reference: Ethan Ozment, Arianna N Tamvacakis, Jianhong Zhou, Pablo Yamild Rosiles-Loeza, Esteban Elías Escobar-Hernandez, Selene L Fernandez-Valverde, Nagayasu Nakanishi. Cnidarian hair cell development illuminates an ancient role for the class IV POU transcription factor in defining mechanoreceptor identity. eLife, 2021; 10 DOI: 10.7554/eLife.74336 Cnidarians, which include jellyfish, corals and sea anemones, are the closest … Read more

A single gene controls species diversity in an ecosystem

Journal Reference: Matthew A. Barbour, Daniel J. Kliebenstein, Jordi Bascompte. A keystone gene underlies the persistence of an experimental food web. Science, 2022; 376 (6588): 70 DOI: 10.1126/science.abf2232 Plant defense genes tested with a simplified ecosystem in the lab A team of ecologists and geneticists at the University of Zurich (UZH) and the University of … Read more

Clock gene mutation found to contribute to the development of autism

Journal Reference: Dong Liu, Carmen Nanclares, Konstanze Simbriger, Kun Fang, Ethan Lorsung, Nam Le, Inês Silva Amorim, Kleanthi Chalkiadaki, Salil Saurav Pathak, Jin Li, Jonathan C. Gewirtz, Victor X. Jin, Paulo Kofuji, Alfonso Araque, Harry T. Orr, Christos G. Gkogkas, Ruifeng Cao. Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition. … Read more

How gene expression changes in the brain in Alzheimer’s disease

Journal Reference: Elena Galea, Laura D. Weinstock, Raquel Larramona-Arcas, Alyssa F. Pybus, Lydia Giménez-Llort, Carole Escartin, Levi B. Wood. Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer’s disease. Neurobiology of Disease, 2022; 166: 105655 DOI: 10.1016/j.nbd.2022.105655 Although Alzheimer’s disease is one of the most studied pathologies due to its high prevalence, … Read more

How can the computer chip predict the future of gene synthesis?

Journal Reference: Joseph Riolo, Andrew J. Steckl. Comparative analysis of genome code complexity and manufacturability with engineering benchmarks. Scientific Reports, 2022; 12 (1) DOI: 10.1038/s41598-022-06723-5 Computer programming and gene synthesis appear to share little in common. But according to University of Cincinnati professor Andrew Steckl, an Ohio Eminent Scholar, leaps forward in technology in the … Read more

Gene allowing humans to feel touch may play a role in sense of smell

Journal Reference: Xiaoyu Liang, Canyon Calovich-Benne, Adam Norris. Sensory neuron transcriptomes reveal complex neuron-specific function and regulation of mec-2/Stomatin splicing. Nucleic Acids Research, 2021; DOI: 10.1093/nar/gkab1134 Researchers from SMU (Southern Methodist University) have determined that a gene linked to feeling touch may moonlight as an olfactory gene. That’s the conclusion drawn from studying a very … Read more

Behind a good mutation: How a gene variant protects against Alzheimer’s

Journal Reference: Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan. The P522R … Read more

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