Skin bacteria may boost immune response of mice vaccinated with smallpox vaccine, study shows

Journal Reference: Evgeniya V. Shmeleva, Mercedes Gomez de Agüero, Josef Wagner, Anton J. Enright, Andrew J. Macpherson, Brian J. Ferguson, Geoffrey L. Smith. Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and influence the host response. PLOS Pathogens, 2022; 18 (4): e1009854 DOI: 10.1371/journal.ppat.1009854 The smallpox vaccination was administered via … Read more

A new understanding of how the immune system deals with malaria

Journal Reference: Maximilian Julius Lautenbach, Victor Yman, Carolina Sousa Silva, Nadir Kadri, Ioanna Broumou, Sherwin Chan, Sina Angenendt, Klara Sondén, David Fernando Plaza, Anna Färnert, Christopher Sundling. Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria. Cell Reports, 2022; 39 (3): 110709 DOI: 10.1016/j.celrep.2022.110709 “Our results contribute to a better … Read more

Key signaling pathway in immune cells could be new Alzheimer’s target

Journal Reference: Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan. Microglial NF-κB drives tau spreading and toxicity in a … Read more

New tool reveals how immune cells find their targets

Journal Reference: Connor S. Dobson, Anna N. Reich, Stephanie Gaglione, Blake E. Smith, Ellen J. Kim, Jiayi Dong, Larance Ronsard, Vintus Okonkwo, Daniel Lingwood, Michael Dougan, Stephanie K. Dougan, Michael E. Birnbaum. Antigen identification and high-throughput interaction mapping by reprogramming viral entry. Nature Methods, 2022; DOI: 10.1038/s41592-022-01436-z MIT biological engineers have now devised an experimental … Read more

Immune responses support COVID-19 vaccination regardless of when people were infected

Journal Reference: Anastasia A. Minervina, Mikhail V. Pogorelyy, Allison M. Kirk, Jeremy Chase Crawford, E. Kaitlynn Allen, Ching-Heng Chou, Robert C. Mettelman, Kim J. Allison, Chun-Yang Lin, David C. Brice, Xun Zhu, Kasi Vegesana, Gang Wu, Sanchit Trivedi, Pratibha Kottapalli, Daniel Darnell, Suzanne McNeely, Scott R. Olsen, Stacey Schultz-Cherry, Jeremie H. Estepp, Aditya Gaur, James … Read more

Immune cells produce chemical messenger that prevents heart disease–related inflammation

Journal Reference: Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee, Nicolas Severe, Brody H. Foy, Fadi E. Pulous, Shuang Zhang, Konstantinos D. Kokkaliaris, Vanessa Frodermann, Gabriel Courties, Chongbo Yang, Yoshiko Iwamoto, Anders Steen Knudsen, Cameron S. McAlpine, Masahiro Yamazoe, Stephen P. Schmidt, Gregory R. Wojtkiewicz, Gustavo Santos Masson, Karin Gustafsson, Diane Capen, Dennis Brown, … Read more

Booster for immune protection after coronavirus infection

Journal Reference: Doris Urlaub, Natalie Wolfsdorff, Jan‐Erik Hoffmann, Stefanie Dorok, Markus Hoffmann, Moritz Anft, Naomi Pieris, Patrick Günther, Bernhard Schaaf, Uwe Cassens, Peter Bröde, Maren Claus, Lea K. Picard, Sabine Wingert, Simone Backes, Deniz Durak, Nina Babel, Stefan Pöhlmann, Frank Renken, Stefan Raunser, Carsten Watzl. Neutralizing antibody responses 300 days after SARS‐CoV‐2 infection and induction … Read more

How coronavirus triggers immune response in brain

Journal Reference: Olumayokun A. Olajide, Victoria U. Iwuanyanwu, Oyinkansola D. Adegbola, Alaa A. Al-Hindawi. SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia. Molecular Neurobiology, 2021; 59 (1): 445 DOI: 10.1007/s12035-021-02593-6 The study, published in the journal Molecular Neurobiology led by the University of Huddersfield’s Dr Mayo Olajide, describes how the spike protein used by … Read more

Weight problems: A dangerous immune response

Journal Reference: Susanne Stutte, Hellen Ishikawa-Ankerhold, Lydia Lynch, Sarah Eickhoff, Simona Nasiscionyte, Chenglong Guo, Dominic van den Heuvel, Daniel Setzensack, Marco Colonna, Daniela Maier-Begandt, Ludwig Weckbach, Thomas Brocker, Christian Schulz, Barbara Walzog, Ulrich von Andrian. High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue. The Journal of Immunology, 2022; … Read more

New study confirms bioengineered RSV protein vaccine evokes protective immune response

Journal Reference: Ana M. Nuñez Castrejon, Sara M. O’Rourke, Lawrence M. Kauvar, Rebecca M. DuBois. Structure-Based Design and Antigenic Validation of Respiratory Syncytial Virus G Immunogens. Journal of Virology, 2022; DOI: 10.1128/jvi.02201-21 For fifth-year Baskin Engineering student and the paper’s lead author Nuñez Castrejon, a bout of pneumonia that lingered for months when she was … Read more

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