Shining a light on protein aggregation in Parkinson’s disease

Journal Reference: Morgan Bérard, Razan Sheta, Sarah Malvaut, Raquel Rodriguez-Aller, Maxime Teixeira, Walid Idi, Roxanne Turmel, Melanie Alpaugh, Marilyn Dubois, Manel Dahmene, Charleen Salesse, Jérôme Lamontagne-Proulx, Marie-Kim St-Pierre, Omid Tavassoly, Wen Luo, Esther Del Cid-Pellitero, Raza Qazi, Jae-Woong Jeong, Thomas M. Durcan, Luc Vallières, Marie-Eve Tremblay, Denis Soulet, Martin Lévesque, Francesca Cicchetti, Edward A. Fon, … Read more

Plant product shows promise in mouse model of Parkinson’s Disease

Journal Reference: Cheng-Peng Sun, Jun-Jun Zhou, Zhen-Long Yu, Xiao-Kui Huo, Juan Zhang, Christophe Morisseau, Bruce D. Hammock, Xiao-Chi Ma. Kurarinone alleviated Parkinson’s disease via stabilization of epoxyeicosatrienoic acids in animal model. Proceedings of the National Academy of Sciences, 2022; 119 (9): e2118818119 DOI: 10.1073/pnas.2118818119 The team found that a soluble epoxide hydrolase (sEH) inhibitor combined … Read more

Treatment for Parkinson’s could now get even better

Journal Reference: Débora Masini, Ole Kiehn. Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-28075-4 Parkinson’s is a neurodegenerative disease where dopaminergic neurons progressively die in the brainstem. Tremor and difficulties to walk are recognizable movement symptoms for many people suffering from Parkinson’s. Over … Read more

Flavonoids may reduce mortality risk for people with Parkinson’s Disease

Journal Reference: Xinyuan Zhang, Samantha A. Molsberry, Tian-Shin Yeh, Aedin Cassidy, Michael A. Schwarzschild, Alberto Ascherio, Xiang Gao. Intake of Flavonoids and Flavonoid-Rich Foods, and Mortality Risk Among Individuals With Parkinson Disease: A Prospective Cohort Study. Neurology, 2022; 10.1212/WNL.0000000000013275 DOI: 10.1212/WNL.0000000000013275 Specifically, the researchers found that when people who had already been diagnosed with Parkinson’s … Read more

Parkinson’s protein blueprint could help fast-track new treatments

Journal Reference: Zhong Yan Gan, Sylvie Callegari, Simon A. Cobbold, Thomas R. Cotton, Michael J. Mlodzianoski, Alexander F. Schubert, Niall D. Geoghegan, Kelly L. Rogers, Andrew Leis, Grant Dewson, Alisa Glukhova, David Komander. Activation mechanism of PINK1. Nature, 2021; DOI: 10.1038/s41586-021-04340-2 The research, published in Nature, has for the first time produced a ‘live action’ … Read more

Parkinson’s disease mutation misdirects iron in the brain

Journal Reference: Adamantios Mamais, Jillian H. Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G. Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C. Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R. Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J. LaVoie, David C. Gershlick, Mark R. Cookson. Mutations in LRRK2 linked to Parkinson disease sequester … Read more

SARS-CoV-2 protein interacts with Parkinson’s protein, promotes amyloid formation, study finds

SARS-CoV-2 protein interacts with Parkinson’s protein, promotes amyloid formation, study finds – NovLink Home Mash I SARS-CoV-2 protein interacts with Parkinson’s protein, promotes amyloid formation, study finds We would like to give thanks to the writer of this article for this incredible web content SARS-CoV-2 protein interacts with Parkinson’s protein, promotes amyloid formation, study finds

Are scientists homing in on a cure for Parkinson’s illness?

Journal Reference: Richard M. Meade, Kathryn J.C. Watt, Robert J. Williams, Jody M. Mason. A Downsized and Optimised Intracellular Library-Derived Peptide Prevents Alpha-Synuclein Primary Nucleation and Toxicity Without Impacting Upon Lipid Binding. Journal of Molecular Biology, 2021; 433 (24): 167323 DOI: 10.1016/j.jmb.2021.167323 Professor Jody Mason, who led the research from the Department of Biology and … Read more

Vascular defects appear to underlie the progression of Parkinson’s disease

Journal Reference: Alan J. Fowler, Jaeil Ahn, Michaeline Hebron, Timothy Chiu, Reem Ayoub, Sanjana Mulki, Habtom Ressom, Yasar Torres-Yaghi, Barbara Wilmarth, Fernando L. Pagan, Charbel Moussa. CSF MicroRNAs Reveal Impairment of Angiogenesis and Autophagy in Parkinson Disease. Neurology Genetics, 2021; 7 (6): e633 DOI: 10.1212/NXG.0000000000000633 The researchers say their finding, detailed in a study published … Read more

Gene therapy boosts Parkinson’s disease drug benefits

Journal Reference: Patricia González-Rodríguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, José López-Barneo, Paul T. Schumacker, D. James Surmeier. Disruption of mitochondrial complex I induces progressive parkinsonism. Nature, 2021; DOI: 10.1038/s41586-021-04059-0 In late-stage Parkinson’s disease, the drug … Read more

Fuzzy Skunk